Drug interactions
Hydrochlorothiazide-valsartan + Nadolol
Severity: Minor
Hydrochlorothiazide-valsartan and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol combined with valsartan and hydrochlorothiazide produces additive blood pressure lowering, which is often intended but can cause hypotension or bradycardia. Beta-blockers may also mask hypoglycemia, and thiazides can worsen glycemic control.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through beta-blockade, RAAS blockade and diuresis.
What to do
Monitor blood pressure and heart rate during initiation and dose changes. Monitor blood glucose in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Nadolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nadolol combined with valsartan and hydrochlorothiazide produces additive blood pressure lowering, which is often intended but can cause hypotension or bradycardia. Beta-blockers may also mask hypoglycemia, and thiazides can worsen glycemic control.
How serious is the interaction between Hydrochlorothiazide-valsartan and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during initiation and dose changes. Monitor blood glucose in diabetic patients.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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