Drug interactions
Hydrochlorothiazide-valsartan + Oliceridine
Severity: Moderate
Hydrochlorothiazide-valsartan and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can promote antidiuretic hormone release, which may blunt the diuretic effect of hydrochlorothiazide. Opioids may also add to hypotension, particularly in volume-depleted patients.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
Why it happens
Opioid-induced ADH release reduces diuresis, and additive hypotensive and orthostatic effects may occur.
What to do
Monitor fluid status, blood pressure and edema; adjust the diuretic dose if diuretic response falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Oliceridine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids can promote antidiuretic hormone release, which may blunt the diuretic effect of hydrochlorothiazide. Opioids may also add to hypotension, particularly in volume-depleted patients.
How serious is the interaction between Hydrochlorothiazide-valsartan and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid status, blood pressure and edema; adjust the diuretic dose if diuretic response falls.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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