Drug interactions
Hydrochlorothiazide-valsartan + Oxaprozin
Severity: Moderate
Hydrochlorothiazide-valsartan and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin can weaken the blood pressure lowering effect of valsartan and hydrochlorothiazide. Together they raise the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced glomerular perfusion, which counteracts the antihypertensive effect and impairs renal function when combined with ARB and diuretic.
What to do
Use the lowest effective NSAID dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Oxaprozin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin can weaken the blood pressure lowering effect of valsartan and hydrochlorothiazide. Together they raise the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
How serious is the interaction between Hydrochlorothiazide-valsartan and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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