Drug interactions
Hydrochlorothiazide-valsartan + Probenecid
Severity: Minor
Hydrochlorothiazide-valsartan and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and probenecid are both secreted by renal organic anion transporters, and probenecid can reduce thiazide tubular secretion. Thiazides also raise serum uric acid, opposing the uricosuric effect of probenecid.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Competition for renal tubular organic anion secretion and thiazide-induced hyperuricemia opposing uricosuria.
What to do
Monitor serum uric acid and gout control. Adjust the probenecid dose or consider an alternative diuretic if efficacy is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Probenecid?
MediHelp rates the interaction as minor. Hydrochlorothiazide-valsartan and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide and probenecid are both secreted by renal organic anion transporters, and probenecid can reduce thiazide tubular secretion. Thiazides also raise serum uric acid, opposing the uricosuric effect of probenecid.
How serious is the interaction between Hydrochlorothiazide-valsartan and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control. Adjust the probenecid dose or consider an alternative diuretic if efficacy is reduced.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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