Drug interactions
Hydrochlorothiazide-valsartan + Ritonavir
Severity: Moderate
Hydrochlorothiazide-valsartan and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits hepatic uptake and efflux transporters involved in valsartan clearance, so valsartan exposure may increase. This could enhance hypotension or renal effects.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of OATP1B1 uptake and MRP2 efflux transport reduces hepatic clearance of valsartan.
What to do
Monitor blood pressure, renal function and potassium when starting or stopping ritonavir; lower the valsartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Ritonavir?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-valsartan and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits hepatic uptake and efflux transporters involved in valsartan clearance, so valsartan exposure may increase. This could enhance hypotension or renal effects.
How serious is the interaction between Hydrochlorothiazide-valsartan and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium when starting or stopping ritonavir; lower the valsartan dose if hypotension occurs.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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