Drug interactions
Hydrochlorothiazide-valsartan + Voclosporin
Severity: Major
Hydrochlorothiazide-valsartan and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause nephrotoxicity, hypertension and hyperkalemia. Combined with valsartan the risks of hyperkalemia and reduced glomerular filtration increase, and diuretic-related volume depletion adds to renal risk.
What this interaction means in plain words
Hydrochlorothiazide-valsartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-valsartan belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibitor afferent arteriolar vasoconstriction combined with ARB efferent dilation and reduced aldosterone effect impairs GFR and potassium excretion.
What to do
Monitor eGFR and serum potassium closely, especially after initiation and dose changes. Reduce or interrupt voclosporin according to labeling if eGFR falls or potassium rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-valsartan with Voclosporin?
MediHelp rates the interaction as major. Hydrochlorothiazide-valsartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin, a calcineurin inhibitor, can cause nephrotoxicity, hypertension and hyperkalemia. Combined with valsartan the risks of hyperkalemia and reduced glomerular filtration increase, and diuretic-related volume depletion adds to renal risk.
How serious is the interaction between Hydrochlorothiazide-valsartan and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR and serum potassium closely, especially after initiation and dose changes. Reduce or interrupt voclosporin according to labeling if eGFR falls or potassium rises.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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