Drug interactions
Hydrocodone + Istradefylline
Severity: Minor
Hydrocodone and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At the higher 40 mg daily dose, istradefylline weakly inhibits CYP3A4 and can increase exposure to CYP3A4 substrates such as hydrocodone. This may heighten opioid effects including sedation and respiratory depression.
What this interaction means in plain words
Hydrocodone and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocodone belongs to Musculoskeletal; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits CYP3A4, decreasing hydrocodone metabolism.
What to do
Monitor for increased opioid effects if istradefylline 40 mg daily is used, and consider lowering the hydrocodone dose. No change is generally needed at 20 mg daily.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Hydrocodone with Istradefylline?
MediHelp rates the interaction as minor. Hydrocodone and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At the higher 40 mg daily dose, istradefylline weakly inhibits CYP3A4 and can increase exposure to CYP3A4 substrates such as hydrocodone. This may heighten opioid effects including sedation and respiratory depression.
How serious is the interaction between Hydrocodone and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased opioid effects if istradefylline 40 mg daily is used, and consider lowering the hydrocodone dose. No change is generally needed at 20 mg daily.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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