Drug interactions
Hydrocodone + Ivosidenib
Severity: Moderate
Hydrocodone and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4, which is the main pathway that converts hydrocodone to inactive norhydrocodone. Hydrocodone exposure may be lowered, which can reduce pain control. Variable changes in metabolism to the active metabolite hydromorphone are also possible.
What this interaction means in plain words
Hydrocodone and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP3A4, accelerating hydrocodone clearance.
What to do
Monitor for reduced analgesia and withdrawal symptoms, and titrate the hydrocodone dose as needed. When ivosidenib is stopped, reassess for opioid toxicity because hydrocodone levels may rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Hydrocodone with Ivosidenib?
MediHelp rates the interaction as moderate. Hydrocodone and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4, which is the main pathway that converts hydrocodone to inactive norhydrocodone. Hydrocodone exposure may be lowered, which can reduce pain control. Variable changes in metabolism to the active metabolite hydromorphone are also possible.
How serious is the interaction between Hydrocodone and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced analgesia and withdrawal symptoms, and titrate the hydrocodone dose as needed. When ivosidenib is stopped, reassess for opioid toxicity because hydrocodone levels may rise.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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