Drug interactions
Hydrocodone + Larotrectinib
Severity: Minor
Hydrocodone and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and has been described as a weak inhibitor of CYP3A4 in vitro, so a modest rise in hydrocodone levels is conceivable. Clinical significance is likely small and the evidence is largely theoretical.
What this interaction means in plain words
Hydrocodone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocodone belongs to Musculoskeletal; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing hydrocodone clearance; not firmly established clinically.
What to do
Monitor for excess sedation or respiratory depression when starting larotrectinib in a patient taking hydrocodone. Adjust the opioid dose only if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Hydrocodone with Larotrectinib?
MediHelp rates the interaction as minor. Hydrocodone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and has been described as a weak inhibitor of CYP3A4 in vitro, so a modest rise in hydrocodone levels is conceivable. Clinical significance is likely small and the evidence is largely theoretical.
How serious is the interaction between Hydrocodone and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation or respiratory depression when starting larotrectinib in a patient taking hydrocodone. Adjust the opioid dose only if symptoms develop.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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