Drug interactions
Hydrocodone + Nilotinib
Severity: Moderate
Hydrocodone and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP2D6 weakly and may modestly alter hydrocodone conversion to hydromorphone. The clinical effect is probably small and unpredictable. Nilotinib also inhibits CYP3A4, which could raise hydrocodone exposure, and both can affect QT or sedation.
What this interaction means in plain words
Hydrocodone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP2D6 and CYP3A4 by nilotinib alters hydrocodone metabolism.
What to do
Monitor analgesia and for opioid adverse effects such as sedation and respiratory depression. Adjust the hydrocodone dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Hydrocodone with Nilotinib?
MediHelp rates the interaction as moderate. Hydrocodone and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP2D6 weakly and may modestly alter hydrocodone conversion to hydromorphone. The clinical effect is probably small and unpredictable. Nilotinib also inhibits CYP3A4, which could raise hydrocodone exposure, and both can affect QT or sedation.
How serious is the interaction between Hydrocodone and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesia and for opioid adverse effects such as sedation and respiratory depression. Adjust the hydrocodone dose according to response.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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