Drug interactions
Hydrocodone + Rasagiline
Severity: Major
Hydrocodone and Rasagiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is an MAO-B inhibitor that may lead to serotonin syndrome or opioid toxicity when combined with opioids. Labeling for opioids advises against use with MAOIs.
What this interaction means in plain words
Hydrocodone and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrocodone belongs to Musculoskeletal; Rasagiline belongs to Central Nervous System.
Why it happens
Monoamine oxidase inhibition may increase serotonergic activity and potentiate opioid effects; selectivity is lost at higher doses.
What to do
Avoid if possible. If an opioid is needed, use low test doses with slow titration and monitor for serotonin toxicity, blood pressure changes and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Hydrocodone with Rasagiline?
MediHelp rates the interaction as major. Hydrocodone and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rasagiline is an MAO-B inhibitor that may lead to serotonin syndrome or opioid toxicity when combined with opioids. Labeling for opioids advises against use with MAOIs.
How serious is the interaction between Hydrocodone and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If an opioid is needed, use low test doses with slow titration and monitor for serotonin toxicity, blood pressure changes and respiratory depression.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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