Drug interactions
Hydrocodone + Safinamide
Severity: Moderate
Hydrocodone and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide is a MAO-B inhibitor, and opioids with serotonergic activity combined with MAO inhibitors may precipitate serotonin syndrome. Hydrocodone has weaker serotonergic activity than agents like meperidine or tramadol, but caution is warranted.
What this interaction means in plain words
Hydrocodone and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Safinamide belongs to Central Nervous System.
Why it happens
MAO-B inhibition by safinamide combined with serotonergic opioid effects.
What to do
Monitor for agitation, tremor, hyperthermia and autonomic instability, especially at initiation. Prefer an opioid with less serotonergic activity if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Hydrocodone with Safinamide?
MediHelp rates the interaction as moderate. Hydrocodone and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Safinamide is a MAO-B inhibitor, and opioids with serotonergic activity combined with MAO inhibitors may precipitate serotonin syndrome. Hydrocodone has weaker serotonergic activity than agents like meperidine or tramadol, but caution is warranted.
How serious is the interaction between Hydrocodone and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia and autonomic instability, especially at initiation. Prefer an opioid with less serotonergic activity if feasible.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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