Drug interactions
Hydrocortisone + Iloperidone
Severity: Minor
Hydrocortisone and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is metabolized by CYP3A4 and CYP2D6. Hydrocortisone is at most a weak CYP3A4 inducer, so clinically relevant reductions in iloperidone exposure are unlikely.
What this interaction means in plain words
Hydrocortisone and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone could marginally increase iloperidone clearance.
What to do
No dose adjustment is required. Monitor psychiatric response if high-dose steroids are used for prolonged periods.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Hydrocortisone with Iloperidone?
MediHelp rates the interaction as minor. Hydrocortisone and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is metabolized by CYP3A4 and CYP2D6. Hydrocortisone is at most a weak CYP3A4 inducer, so clinically relevant reductions in iloperidone exposure are unlikely.
How serious is the interaction between Hydrocortisone and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor psychiatric response if high-dose steroids are used for prolonged periods.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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