Drug interactions
Hydrocortisone + Indacaterol-glycopyrronium
Severity: Moderate
Hydrocortisone and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol may lower serum potassium, and systemic corticosteroids with mineralocorticoid activity promote potassium excretion. The combination may cause additive hypokalemia, which raises arrhythmia risk in susceptible patients.
What this interaction means in plain words
Hydrocortisone and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 agonist-induced intracellular potassium shift and corticosteroid-induced renal potassium wasting.
What to do
Check serum potassium when systemic hydrocortisone is given with indacaterol, especially in severe COPD or with other potassium-lowering drugs. Correct hypokalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Hydrocortisone and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol may lower serum potassium, and systemic corticosteroids with mineralocorticoid activity promote potassium excretion. The combination may cause additive hypokalemia, which raises arrhythmia risk in susceptible patients.
How serious is the interaction between Hydrocortisone and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium when systemic hydrocortisone is given with indacaterol, especially in severe COPD or with other potassium-lowering drugs. Correct hypokalemia promptly.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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