Drug interactions
Hydrocortisone + Ivacaftor
Severity: Minor
Hydrocortisone and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its metabolite weakly inhibit P-glycoprotein and may raise concentrations of P-gp substrates. Hydrocortisone is not a narrow-therapeutic-index substrate, so the effect is likely small.
What this interaction means in plain words
Hydrocortisone and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Ivacaftor belongs to Miscellaneous.
Why it happens
Ivacaftor and its M1 metabolite inhibit P-gp, potentially increasing hydrocortisone exposure.
What to do
No dose change is generally needed. Monitor for glucocorticoid excess with prolonged high-dose therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Hydrocortisone with Ivacaftor?
MediHelp rates the interaction as minor. Hydrocortisone and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor and its metabolite weakly inhibit P-glycoprotein and may raise concentrations of P-gp substrates. Hydrocortisone is not a narrow-therapeutic-index substrate, so the effect is likely small.
How serious is the interaction between Hydrocortisone and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for glucocorticoid excess with prolonged high-dose therapy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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