Drug interactions
Hydrocortisone + Lasmiditan
Severity: Minor
Hydrocortisone and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits intestinal P-glycoprotein and may modestly raise exposure to P-gp substrates such as hydrocortisone. Hydrocortisone has a wide therapeutic index, so clinical impact is expected to be small.
What this interaction means in plain words
Hydrocortisone and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan inhibits P-glycoprotein efflux, increasing hydrocortisone absorption and exposure.
What to do
No routine adjustment is needed; monitor for signs of corticosteroid excess in patients on long-term hydrocortisone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Hydrocortisone with Lasmiditan?
MediHelp rates the interaction as minor. Hydrocortisone and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits intestinal P-glycoprotein and may modestly raise exposure to P-gp substrates such as hydrocortisone. Hydrocortisone has a wide therapeutic index, so clinical impact is expected to be small.
How serious is the interaction between Hydrocortisone and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for signs of corticosteroid excess in patients on long-term hydrocortisone.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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