Drug interactions
Hydrocortisone + Letermovir
Severity: Moderate
Hydrocortisone and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 and may increase hydrocortisone exposure. Prolonged use could cause greater glucocorticoid effects.
What this interaction means in plain words
Hydrocortisone and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4 and reduces hydrocortisone clearance.
What to do
Monitor for glucocorticoid excess such as hyperglycemia, hypertension and fluid retention. Reduce the hydrocortisone dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Hydrocortisone with Letermovir?
MediHelp rates the interaction as moderate. Hydrocortisone and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A4 and may increase hydrocortisone exposure. Prolonged use could cause greater glucocorticoid effects.
How serious is the interaction between Hydrocortisone and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for glucocorticoid excess such as hyperglycemia, hypertension and fluid retention. Reduce the hydrocortisone dose if these occur.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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