Drug interactions
Hydrocortisone + Lonafarnib
Severity: Minor
Hydrocortisone and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-glycoprotein inhibitor and could slightly raise hydrocortisone concentrations. A clinically significant effect is unlikely.
What this interaction means in plain words
Hydrocortisone and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Lonafarnib belongs to Miscellaneous.
Why it happens
Weak inhibition of P-glycoprotein efflux by lonafarnib.
What to do
No routine adjustment is needed. Monitor for corticosteroid adverse effects and reduce the hydrocortisone dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Hydrocortisone with Lonafarnib?
MediHelp rates the interaction as minor. Hydrocortisone and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a weak P-glycoprotein inhibitor and could slightly raise hydrocortisone concentrations. A clinically significant effect is unlikely.
How serious is the interaction between Hydrocortisone and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for corticosteroid adverse effects and reduce the hydrocortisone dose if they occur.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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