Drug interactions
Hydrocortisone + Lornoxicam
Severity: Moderate
Hydrocortisone and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with lornoxicam raises the risk of gastric ulceration and gastrointestinal bleeding. The risk increases with age, higher doses and longer treatment.
What this interaction means in plain words
Hydrocortisone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury from NSAID prostaglandin inhibition and corticosteroid impairment of healing.
What to do
Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor in patients at GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Hydrocortisone with Lornoxicam?
MediHelp rates the interaction as moderate. Hydrocortisone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with lornoxicam raises the risk of gastric ulceration and gastrointestinal bleeding. The risk increases with age, higher doses and longer treatment.
How serious is the interaction between Hydrocortisone and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor in patients at GI risk.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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