Drug interactions
Hydrocortisone + Macimorelin
Severity: Moderate
Hydrocortisone and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucocorticoids such as hydrocortisone can alter pituitary growth hormone secretion. This may distort the result of the macimorelin growth hormone stimulation test and lead to misdiagnosis of growth hormone deficiency.
What this interaction means in plain words
Hydrocortisone and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Macimorelin belongs to Endocrine.
Why it happens
Pharmacodynamic: corticosteroids modulate pituitary GH release and so interfere with the stimulation test response.
What to do
Where clinically possible, allow an adequate washout of hydrocortisone before macimorelin testing, or interpret the result with caution if replacement therapy cannot be stopped. Do not withdraw replacement in adrenal insufficiency without specialist guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Hydrocortisone with Macimorelin?
MediHelp rates the interaction as moderate. Hydrocortisone and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucocorticoids such as hydrocortisone can alter pituitary growth hormone secretion. This may distort the result of the macimorelin growth hormone stimulation test and lead to misdiagnosis of growth hormone deficiency.
How serious is the interaction between Hydrocortisone and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where clinically possible, allow an adequate washout of hydrocortisone before macimorelin testing, or interpret the result with caution if replacement therapy cannot be stopped. Do not withdraw replacement in adrenal insufficiency without specialist guidance.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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