Drug interactions
Hydrocortisone + Mesterolone
Severity: Minor
Hydrocortisone and Mesterolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both corticosteroids and androgens can cause sodium and fluid retention, so combined use may increase edema. This is mainly a concern in patients with heart failure, hypertension or renal impairment.
What this interaction means in plain words
Hydrocortisone and Mesterolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Mesterolone belongs to Endocrine.
Why it happens
Additive sodium and water retention from mineralocorticoid activity and androgen effects.
What to do
Monitor weight, blood pressure and signs of edema, especially in patients with cardiac or renal disease. Adjust therapy if fluid retention develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Mesterolone
Frequently asked questions
Can I take Hydrocortisone with Mesterolone?
MediHelp rates the interaction as minor. Hydrocortisone and Mesterolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both corticosteroids and androgens can cause sodium and fluid retention, so combined use may increase edema. This is mainly a concern in patients with heart failure, hypertension or renal impairment.
How serious is the interaction between Hydrocortisone and Mesterolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, blood pressure and signs of edema, especially in patients with cardiac or renal disease. Adjust therapy if fluid retention develops.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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