Drug interactions
Hydrocortisone + Moxifloxacin
Severity: Major
Hydrocortisone and Moxifloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones carry a risk of tendinitis and tendon rupture, and concurrent systemic corticosteroid use increases that risk further. The Achilles tendon is most often affected, and older patients are most vulnerable.
What this interaction means in plain words
Hydrocortisone and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrocortisone belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive tendon toxicity; fluoroquinolones and corticosteroids both impair tenocyte function and collagen integrity.
What to do
Avoid the combination where an alternative antibiotic is suitable, especially in patients over 60 or with renal impairment. Stop the quinolone and rest the limb at the first sign of tendon pain.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Hydrocortisone with Moxifloxacin?
MediHelp rates the interaction as major. Hydrocortisone and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones carry a risk of tendinitis and tendon rupture, and concurrent systemic corticosteroid use increases that risk further. The Achilles tendon is most often affected, and older patients are most vulnerable.
How serious is the interaction between Hydrocortisone and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antibiotic is suitable, especially in patients over 60 or with renal impairment. Stop the quinolone and rest the limb at the first sign of tendon pain.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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