Drug interactions
Hydrocortisone + Nabumetone
Severity: Moderate
Hydrocortisone and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-administration of a corticosteroid and an NSAID increases the risk of peptic ulceration and gastrointestinal bleeding. Risk rises with higher doses, longer treatment and older age.
What this interaction means in plain words
Hydrocortisone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic mucosal injury through NSAID prostaglandin suppression and corticosteroid impairment of healing.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in at-risk patients. Monitor for GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Hydrocortisone with Nabumetone?
MediHelp rates the interaction as moderate. Hydrocortisone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Co-administration of a corticosteroid and an NSAID increases the risk of peptic ulceration and gastrointestinal bleeding. Risk rises with higher doses, longer treatment and older age.
How serious is the interaction between Hydrocortisone and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in at-risk patients. Monitor for GI bleeding.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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