Drug interactions
Hydrocortisone + Piroxicam
Severity: Moderate
Hydrocortisone and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking a corticosteroid together with piroxicam increases the risk of peptic ulceration and gastrointestinal bleeding. Piroxicam carries a relatively high GI risk among NSAIDs.
What this interaction means in plain words
Hydrocortisone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Piroxicam belongs to Musculoskeletal.
Why it happens
Additive mucosal injury from NSAID prostaglandin inhibition and corticosteroid impairment of healing.
What to do
Avoid long-term combined use where possible, or add a proton pump inhibitor. Monitor for dyspepsia, melena and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Hydrocortisone with Piroxicam?
MediHelp rates the interaction as moderate. Hydrocortisone and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking a corticosteroid together with piroxicam increases the risk of peptic ulceration and gastrointestinal bleeding. Piroxicam carries a relatively high GI risk among NSAIDs.
How serious is the interaction between Hydrocortisone and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combined use where possible, or add a proton pump inhibitor. Monitor for dyspepsia, melena and anemia.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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