Drug interactions
Hydrocortisone + Rosiglitazone
Severity: Moderate
Hydrocortisone and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone raises blood glucose and can reduce the glucose-lowering effect of rosiglitazone. Both drugs can also cause fluid retention.
What this interaction means in plain words
Hydrocortisone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Glucocorticoid-induced insulin resistance opposes rosiglitazone; additive fluid retention may occur.
What to do
Monitor blood glucose and adjust antidiabetic therapy during steroid use. Watch for edema and weight gain, especially in patients with heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Hydrocortisone with Rosiglitazone?
MediHelp rates the interaction as moderate. Hydrocortisone and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone raises blood glucose and can reduce the glucose-lowering effect of rosiglitazone. Both drugs can also cause fluid retention.
How serious is the interaction between Hydrocortisone and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and adjust antidiabetic therapy during steroid use. Watch for edema and weight gain, especially in patients with heart failure.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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