Drug interactions
Hydrocortisone + Tazemetostat
Severity: Minor
Hydrocortisone and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a CYP3A4 substrate, and hydrocortisone is at most a weak CYP3A4 inducer. A clinically relevant reduction in tazemetostat exposure is unlikely.
What this interaction means in plain words
Hydrocortisone and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocortisone belongs to Endocrine; Tazemetostat belongs to Miscellaneous.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone increasing tazemetostat metabolism.
What to do
No dose change is needed. Monitor clinical response to tazemetostat.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Hydrocortisone with Tazemetostat?
MediHelp rates the interaction as minor. Hydrocortisone and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a CYP3A4 substrate, and hydrocortisone is at most a weak CYP3A4 inducer. A clinically relevant reduction in tazemetostat exposure is unlikely.
How serious is the interaction between Hydrocortisone and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor clinical response to tazemetostat.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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