Drug interactions
Hydrocortisone + Testosterone
Severity: Moderate
Hydrocortisone and Testosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both androgens and corticosteroids can cause sodium and water retention, so combined use may produce edema. This is most relevant in patients with heart, kidney, or liver disease.
What this interaction means in plain words
Hydrocortisone and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Testosterone belongs to Endocrine.
Why it happens
Additive sodium and fluid retention from androgenic and mineralocorticoid effects.
What to do
Monitor body weight, edema, and blood pressure, particularly in patients with cardiac, renal, or hepatic disease. Adjust therapy or add diuretics if fluid retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Frequently asked questions
Can I take Hydrocortisone with Testosterone?
MediHelp rates the interaction as moderate. Hydrocortisone and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both androgens and corticosteroids can cause sodium and water retention, so combined use may produce edema. This is most relevant in patients with heart, kidney, or liver disease.
How serious is the interaction between Hydrocortisone and Testosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor body weight, edema, and blood pressure, particularly in patients with cardiac, renal, or hepatic disease. Adjust therapy or add diuretics if fluid retention develops.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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