Drug interactions
Hydrocortisone + Tipranavir
Severity: Moderate
Hydrocortisone and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir (usually given with ritonavir) is a net strong CYP3A4 inhibitor and so can increase hydrocortisone exposure. Hydrocortisone might weakly lower tipranavir levels, but this is less relevant.
What this interaction means in plain words
Hydrocortisone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4, increasing hydrocortisone exposure, while weak hydrocortisone induction may slightly reduce tipranavir.
What to do
Monitor for signs of glucocorticoid excess with prolonged use and reduce the hydrocortisone dose if needed. Follow HIV viral load as scheduled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Hydrocortisone with Tipranavir?
MediHelp rates the interaction as moderate. Hydrocortisone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir (usually given with ritonavir) is a net strong CYP3A4 inhibitor and so can increase hydrocortisone exposure. Hydrocortisone might weakly lower tipranavir levels, but this is less relevant.
How serious is the interaction between Hydrocortisone and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of glucocorticoid excess with prolonged use and reduce the hydrocortisone dose if needed. Follow HIV viral load as scheduled.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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