Drug interactions
Hydrocortisone + Trastuzumab deruxtecan
Severity: Moderate
Hydrocortisone and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can impair immune defenses, with trastuzumab deruxtecan causing neutropenia and corticosteroids suppressing immune function. Combined use may raise infection risk. Corticosteroids are, however, often used as premedication or to treat interstitial lung disease with this drug.
What this interaction means in plain words
Hydrocortisone and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression-related infection risk.
What to do
Monitor blood counts and watch for signs of infection during prolonged steroid use. Keep steroid exposure to what is clinically necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Hydrocortisone with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Hydrocortisone and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can impair immune defenses, with trastuzumab deruxtecan causing neutropenia and corticosteroids suppressing immune function. Combined use may raise infection risk. Corticosteroids are, however, often used as premedication or to treat interstitial lung disease with this drug.
How serious is the interaction between Hydrocortisone and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for signs of infection during prolonged steroid use. Keep steroid exposure to what is clinically necessary.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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