Drug interactions
Hydrocortisone + Voriconazole
Severity: Moderate
Hydrocortisone and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and can raise hydrocortisone exposure, increasing the risk of Cushingoid effects and adrenal suppression with prolonged use. Azole antifungals have been associated with this effect for systemic corticosteroids.
What this interaction means in plain words
Hydrocortisone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibition of CYP3A4 reduces hydrocortisone clearance.
What to do
Consider reducing the hydrocortisone dose when treatment is prolonged and monitor for steroid excess such as hyperglycemia and hypertension. Watch for adrenal suppression when the azole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Hydrocortisone with Voriconazole?
MediHelp rates the interaction as moderate. Hydrocortisone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and can raise hydrocortisone exposure, increasing the risk of Cushingoid effects and adrenal suppression with prolonged use. Azole antifungals have been associated with this effect for systemic corticosteroids.
How serious is the interaction between Hydrocortisone and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the hydrocortisone dose when treatment is prolonged and monitor for steroid excess such as hyperglycemia and hypertension. Watch for adrenal suppression when the azole is stopped.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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