Drug interactions
Hydrocortisone rectal + Moxifloxacin
Severity: Minor
Hydrocortisone rectal and Moxifloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones raise the risk of tendinopathy and tendon rupture, and concurrent corticosteroids increase that risk further. Rectal hydrocortisone has lower systemic exposure than oral or injected steroid, but absorption can be meaningful with prolonged or high-dose use.
What this interaction means in plain words
Hydrocortisone rectal and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive tendon toxicity from fluoroquinolone-related collagen and tenocyte injury and corticosteroid effects on tendon structure.
What to do
Advise patients to stop moxifloxacin and report promptly if tendon pain or swelling occurs. Be especially watchful in older patients or with prolonged steroid use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Hydrocortisone rectal with Moxifloxacin?
MediHelp rates the interaction as minor. Hydrocortisone rectal and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoroquinolones raise the risk of tendinopathy and tendon rupture, and concurrent corticosteroids increase that risk further. Rectal hydrocortisone has lower systemic exposure than oral or injected steroid, but absorption can be meaningful with prolonged or high-dose use.
How serious is the interaction between Hydrocortisone rectal and Moxifloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to stop moxifloxacin and report promptly if tendon pain or swelling occurs. Be especially watchful in older patients or with prolonged steroid use.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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