Drug interactions
Hydromorphone + Loxapine inhaled
Severity: Moderate
Hydromorphone and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine is a sedating antipsychotic, and with an opioid the CNS depressant effects are additive. Inhaled loxapine can also cause bronchospasm, which is a concern in patients with respiratory compromise who are receiving opioids.
What this interaction means in plain words
Hydromorphone and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine, histamine and muscarinic receptor antagonism combined with opioid agonism.
What to do
Monitor sedation and respiratory status after loxapine dosing, and consider reducing the opioid dose. Observe patients for bronchospasm after inhalation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Hydromorphone with Loxapine inhaled?
MediHelp rates the interaction as moderate. Hydromorphone and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine is a sedating antipsychotic, and with an opioid the CNS depressant effects are additive. Inhaled loxapine can also cause bronchospasm, which is a concern in patients with respiratory compromise who are receiving opioids.
How serious is the interaction between Hydromorphone and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status after loxapine dosing, and consider reducing the opioid dose. Observe patients for bronchospasm after inhalation.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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