Drug interactions
Hydromorphone + Marijuana
Severity: Moderate
Hydromorphone and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis has sedative and psychomotor-impairing effects that add to the CNS depression caused by opioids. This may increase drowsiness, dizziness, impaired coordination and cognitive impairment.
What this interaction means in plain words
Hydromorphone and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS depression via cannabinoid and opioid receptor effects.
What to do
Counsel patients on increased sedation and impairment, and avoid driving or hazardous tasks. Monitor sedation and consider lowering the opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Hydromorphone with Marijuana?
MediHelp rates the interaction as moderate. Hydromorphone and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis has sedative and psychomotor-impairing effects that add to the CNS depression caused by opioids. This may increase drowsiness, dizziness, impaired coordination and cognitive impairment.
How serious is the interaction between Hydromorphone and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on increased sedation and impairment, and avoid driving or hazardous tasks. Monitor sedation and consider lowering the opioid dose.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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