Drug interactions
Hydromorphone + Metoclopramide intranasal
Severity: Moderate
Hydromorphone and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying and gut motility, which opposes the prokinetic effect of metoclopramide. Both can also add to CNS effects such as drowsiness.
What this interaction means in plain words
Hydromorphone and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism of prokinetic action by opioid-induced reduction in gastrointestinal motility, with some additive CNS effects.
What to do
Monitor for reduced metoclopramide efficacy and for sedation; consider an alternative approach for gastroparesis if opioids must continue.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Hydromorphone with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Hydromorphone and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying and gut motility, which opposes the prokinetic effect of metoclopramide. Both can also add to CNS effects such as drowsiness.
How serious is the interaction between Hydromorphone and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced metoclopramide efficacy and for sedation; consider an alternative approach for gastroparesis if opioids must continue.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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