Drug interactions
Hydromorphone + Sage
Severity: Minor
Hydromorphone and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some sage preparations may have mild sedative effects, so additive drowsiness with hydromorphone is theoretically possible. Evidence is lacking and the effect is likely small.
What this interaction means in plain words
Hydromorphone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; the mechanism is theoretical and not well established.
What to do
Counsel patients to report excess sedation when taking sage supplements with hydromorphone. No routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Hydromorphone with Sage?
MediHelp rates the interaction as minor. Hydromorphone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some sage preparations may have mild sedative effects, so additive drowsiness with hydromorphone is theoretically possible. Evidence is lacking and the effect is likely small.
How serious is the interaction between Hydromorphone and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report excess sedation when taking sage supplements with hydromorphone. No routine dose change is required.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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