Drug interactions
Hydromorphone + Thiothixene
Severity: Moderate
Hydromorphone and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is a sedating antipsychotic that can add to opioid-induced drowsiness and respiratory depression. Hypotension and impaired psychomotor function may also be increased.
What this interaction means in plain words
Hydromorphone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through opioid agonism and antipsychotic antihistaminic/antiadrenergic effects.
What to do
Start with reduced hydromorphone doses and titrate slowly while monitoring sedation, blood pressure and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Hydromorphone with Thiothixene?
MediHelp rates the interaction as moderate. Hydromorphone and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is a sedating antipsychotic that can add to opioid-induced drowsiness and respiratory depression. Hypotension and impaired psychomotor function may also be increased.
How serious is the interaction between Hydromorphone and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced hydromorphone doses and titrate slowly while monitoring sedation, blood pressure and respiration.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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