Drug interactions
Hydromorphone + Topiramate
Severity: Moderate
Hydromorphone and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness and cognitive slowing, so together they may produce additive CNS depression. The effect is usually manageable but can impair alertness and psychomotor performance.
What this interaction means in plain words
Hydromorphone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Topiramate belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depressant effects.
What to do
Warn patients about sedation and avoid driving until response is known. Titrate slowly and lower the opioid dose if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Topiramate
Frequently asked questions
Can I take Hydromorphone with Topiramate?
MediHelp rates the interaction as moderate. Hydromorphone and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause drowsiness and cognitive slowing, so together they may produce additive CNS depression. The effect is usually manageable but can impair alertness and psychomotor performance.
How serious is the interaction between Hydromorphone and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about sedation and avoid driving until response is known. Titrate slowly and lower the opioid dose if excessive drowsiness occurs.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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