Drug interactions
Hydromorphone + Triprolidine
Severity: Major
Hydromorphone and Triprolidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating first-generation antihistamine with an opioid increases drowsiness, psychomotor impairment and the risk of respiratory depression. Elderly or opioid-naive patients and those with lung disease are at greatest risk.
What this interaction means in plain words
Hydromorphone and Triprolidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydromorphone belongs to Musculoskeletal; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS and respiratory depression through different pharmacodynamic pathways.
What to do
Avoid triprolidine with hydromorphone where possible, or use the lowest effective doses and monitor sedation and respiratory rate. Advise the patient not to drive and to avoid alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Triprolidine
Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Hydromorphone with Triprolidine?
MediHelp rates the interaction as major. Hydromorphone and Triprolidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a sedating first-generation antihistamine with an opioid increases drowsiness, psychomotor impairment and the risk of respiratory depression. Elderly or opioid-naive patients and those with lung disease are at greatest risk.
How serious is the interaction between Hydromorphone and Triprolidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid triprolidine with hydromorphone where possible, or use the lowest effective doses and monitor sedation and respiratory rate. Advise the patient not to drive and to avoid alcohol.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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