Drug interactions
Hydroxycarbamide + Idarubicin
Severity: Moderate
Hydroxycarbamide and Idarubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow, so combined use can cause deeper and longer neutropenia, anemia and thrombocytopenia. This is often expected in leukemia regimens but requires supportive care.
What this interaction means in plain words
Hydroxycarbamide and Idarubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxycarbamide belongs to Oncology; Idarubicin belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Monitor complete blood counts frequently and adjust doses or provide supportive care per protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Hydroxycarbamide with Idarubicin?
MediHelp rates the interaction as moderate. Hydroxycarbamide and Idarubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow, so combined use can cause deeper and longer neutropenia, anemia and thrombocytopenia. This is often expected in leukemia regimens but requires supportive care.
How serious is the interaction between Hydroxycarbamide and Idarubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and adjust doses or provide supportive care per protocol.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
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