Drug interactions
Albuterol + Hydroxychloroquine
Severity: Moderate
Albuterol and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine prolongs the QT interval, and high-dose or systemic albuterol can add to this through hypokalemia and sympathomimetic effects. The risk is mainly relevant with nebulized high doses, in patients with cardiac disease or electrolyte disturbance.
What this interaction means in plain words
Albuterol and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia and tachycardia contributing to arrhythmia risk.
What to do
Use standard inhaled albuterol doses and monitor potassium in patients needing frequent or high-dose use. Obtain an ECG if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Albuterol with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Albuterol and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxychloroquine prolongs the QT interval, and high-dose or systemic albuterol can add to this through hypokalemia and sympathomimetic effects. The risk is mainly relevant with nebulized high doses, in patients with cardiac disease or electrolyte disturbance.
How serious is the interaction between Albuterol and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use standard inhaled albuterol doses and monitor potassium in patients needing frequent or high-dose use. Obtain an ECG if the patient has other QT risk factors.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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