Drug interactions
Dronedarone + Hydroxychloroquine
Severity: Contraindicated
Dronedarone and Hydroxychloroquine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone prolongs the QT interval and hydroxychloroquine adds to this effect, increasing the risk of torsades de pointes. Dronedarone's labeling advises against combination with QT-prolonging drugs.
What this interaction means in plain words
Dronedarone and Hydroxychloroquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive delayed ventricular repolarization through potassium channel blockade.
What to do
Do not combine; choose an alternative antiarrhythmic or an alternative to hydroxychloroquine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
- Adagrasib + Hydroxychloroquine Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Hydroxychloroquine?
MediHelp rates the interaction as contraindicated. Dronedarone and Hydroxychloroquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dronedarone prolongs the QT interval and hydroxychloroquine adds to this effect, increasing the risk of torsades de pointes. Dronedarone's labeling advises against combination with QT-prolonging drugs.
How serious is the interaction between Dronedarone and Hydroxychloroquine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an alternative antiarrhythmic or an alternative to hydroxychloroquine.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Pimozide. The full list is on the Hydroxychloroquine page.
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