Drug interactions
Hydroxychloroquine + Thioridazine
Severity: Contraindicated
Hydroxychloroquine and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine is strongly associated with QT prolongation and torsades de pointes, and hydroxychloroquine adds to the risk. Thioridazine labeling contraindicates use with other drugs that prolong the QT interval.
What this interaction means in plain words
Hydroxychloroquine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydroxychloroquine belongs to Musculoskeletal; Thioridazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation via potassium channel blockade.
What to do
Do not combine; use an alternative antipsychotic or a different antimalarial or antirheumatic agent.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
- Adagrasib + Hydroxychloroquine Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Thioridazine?
MediHelp rates the interaction as contraindicated. Hydroxychloroquine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is strongly associated with QT prolongation and torsades de pointes, and hydroxychloroquine adds to the risk. Thioridazine labeling contraindicates use with other drugs that prolong the QT interval.
How serious is the interaction between Hydroxychloroquine and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative antipsychotic or a different antimalarial or antirheumatic agent.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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