Drug interactions
Cisapride + Hydroxychloroquine
Severity: Contraindicated
Cisapride and Hydroxychloroquine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine can prolong the QT interval and, with cisapride, increases the risk of torsades de pointes.
What this interaction means in plain words
Cisapride and Hydroxychloroquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cisapride belongs to Gastrointestinal Tract; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive inhibition of cardiac potassium channels with QT prolongation.
What to do
Avoid the combination and use an alternative prokinetic. If unavoidable, monitor the ECG and keep potassium and magnesium within normal limits.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
- Adagrasib + Hydroxychloroquine Major
Frequently asked questions
Can I take Cisapride with Hydroxychloroquine?
MediHelp rates the interaction as contraindicated. Cisapride and Hydroxychloroquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydroxychloroquine can prolong the QT interval and, with cisapride, increases the risk of torsades de pointes.
How serious is the interaction between Cisapride and Hydroxychloroquine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative prokinetic. If unavoidable, monitor the ECG and keep potassium and magnesium within normal limits.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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