Drug interactions
Hydroxyprogesterone caproate + Itraconazole
Severity: Moderate
Hydroxyprogesterone caproate and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise hydroxyprogesterone caproate concentrations because the progestin is partly metabolized by CYP3A4. Higher exposure could increase progestogenic adverse effects, though clinical data are limited.
What this interaction means in plain words
Hydroxyprogesterone caproate and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Itraconazole inhibits CYP3A4, reducing the metabolism of hydroxyprogesterone caproate.
What to do
Monitor for increased progestogenic effects such as fluid retention, hypertension, and glucose intolerance. Consider an alternative antifungal if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Itraconazole?
MediHelp rates the interaction as moderate. Hydroxyprogesterone caproate and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may raise hydroxyprogesterone caproate concentrations because the progestin is partly metabolized by CYP3A4. Higher exposure could increase progestogenic adverse effects, though clinical data are limited.
How serious is the interaction between Hydroxyprogesterone caproate and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased progestogenic effects such as fluid retention, hypertension, and glucose intolerance. Consider an alternative antifungal if toxicity appears.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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