Drug interactions
Hydroxyprogesterone caproate + Ribociclib
Severity: Minor
Hydroxyprogesterone caproate and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may slow the hepatic metabolism of hydroxyprogesterone caproate, which is partly cleared by CYP3A4. Exposure may rise, though the clinical relevance is uncertain.
What this interaction means in plain words
Hydroxyprogesterone caproate and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated metabolism by ribociclib.
What to do
No routine dose change is needed; watch for progestogenic adverse effects such as fluid retention or injection-site and hepatic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydroxyprogesterone caproate and Ribociclib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Ribociclib?
MediHelp rates the interaction as minor. Hydroxyprogesterone caproate and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may slow the hepatic metabolism of hydroxyprogesterone caproate, which is partly cleared by CYP3A4. Exposure may rise, though the clinical relevance is uncertain.
How serious is the interaction between Hydroxyprogesterone caproate and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for progestogenic adverse effects such as fluid retention or injection-site and hepatic effects.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
