Drug interactions
Hydroxyprogesterone caproate + Voriconazole
Severity: Minor
Hydroxyprogesterone caproate and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyprogesterone caproate is metabolized partly by CYP3A4, so voriconazole may raise its levels. Clinical consequences are not well characterized and the effect is probably small.
What this interaction means in plain words
Hydroxyprogesterone caproate and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of hydroxyprogesterone caproate.
What to do
No dose change is generally needed; monitor for progestogen-related adverse effects such as fluid retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydroxyprogesterone caproate and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Voriconazole?
MediHelp rates the interaction as minor. Hydroxyprogesterone caproate and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyprogesterone caproate is metabolized partly by CYP3A4, so voriconazole may raise its levels. Clinical consequences are not well characterized and the effect is probably small.
How serious is the interaction between Hydroxyprogesterone caproate and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for progestogen-related adverse effects such as fluid retention.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
