Drug interactions
Hydroxyurea + Lenalidomide
Severity: Moderate
Hydroxyurea and Lenalidomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause myelosuppression, so combined use can deepen neutropenia, thrombocytopenia and anemia. This raises the risk of infection and bleeding.
What this interaction means in plain words
Hydroxyurea and Lenalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Lenalidomide belongs to Oncology.
Why it happens
Additive bone marrow suppression through different mechanisms.
What to do
Monitor complete blood counts frequently, particularly in the first weeks. Reduce or interrupt doses according to lenalidomide labeling for cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lenalidomide
- Deferiprone + Lenalidomide Major
- Lenalidomide + Ropeginterferon alfa 2b Major
- Acalabrutinib + Lenalidomide Moderate
- Anakinra + Lenalidomide Moderate
- Cholera vaccine + Lenalidomide Moderate
- Denosumab + Lenalidomide Moderate
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Lenalidomide?
MediHelp rates the interaction as moderate. Hydroxyurea and Lenalidomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause myelosuppression, so combined use can deepen neutropenia, thrombocytopenia and anemia. This raises the risk of infection and bleeding.
How serious is the interaction between Hydroxyurea and Lenalidomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, particularly in the first weeks. Reduce or interrupt doses according to lenalidomide labeling for cytopenias.
What other medicines interact with Lenalidomide?
MediHelp also lists interactions of Lenalidomide with, for example, Deferiprone, Ropeginterferon alfa 2b, Acalabrutinib. The full list is on the Lenalidomide page.
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