Drug interactions
Hydroxyurea + Paclitaxel
Severity: Moderate
Hydroxyurea and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow, so combined use may cause greater neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding.
What this interaction means in plain words
Hydroxyurea and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Paclitaxel belongs to Oncology.
Why it happens
Additive myelosuppressive pharmacodynamic effects.
What to do
Monitor complete blood counts regularly and adjust doses or delay treatment based on counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Paclitaxel?
MediHelp rates the interaction as moderate. Hydroxyurea and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow, so combined use may cause greater neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding.
How serious is the interaction between Hydroxyurea and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust doses or delay treatment based on counts.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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