Drug interactions
Hydroxyurea + Probenecid
Severity: Moderate
Hydroxyurea and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyurea can raise serum uric acid, which may counteract the effect of probenecid and require gout therapy adjustment. A direct effect on probenecid levels is not well established.
What this interaction means in plain words
Hydroxyurea and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Probenecid belongs to Genitourinary.
Why it happens
Hydroxyurea-related hyperuricemia from increased cell turnover opposes probenecid pharmacodynamically; a pharmacokinetic mechanism is not established.
What to do
Monitor serum uric acid and renal function. Adjust the dose of the uric acid-lowering therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Probenecid?
MediHelp rates the interaction as moderate. Hydroxyurea and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyurea can raise serum uric acid, which may counteract the effect of probenecid and require gout therapy adjustment. A direct effect on probenecid levels is not well established.
How serious is the interaction between Hydroxyurea and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and renal function. Adjust the dose of the uric acid-lowering therapy as required.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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