Drug interactions
Hydroxyurea + Procarbazine
Severity: Moderate
Hydroxyurea and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress bone marrow function, and together they can cause marked leukopenia and thrombocytopenia. This raises the risk of infections and bleeding.
What this interaction means in plain words
Hydroxyurea and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Procarbazine belongs to Oncology.
Why it happens
Additive myelosuppression from two cytotoxic agents.
What to do
Monitor complete blood counts at regular intervals and modify doses or hold therapy for severe cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyurea
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Hydroxyurea with Procarbazine?
MediHelp rates the interaction as moderate. Hydroxyurea and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress bone marrow function, and together they can cause marked leukopenia and thrombocytopenia. This raises the risk of infections and bleeding.
How serious is the interaction between Hydroxyurea and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts at regular intervals and modify doses or hold therapy for severe cytopenias.
What other medicines interact with Hydroxyurea?
MediHelp also lists interactions of Hydroxyurea with, for example, Didanosine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Hydroxyurea page.
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